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Literature review biological safety of parylene c

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Subchronic, chronic, and carcinogenicity testing can add several thousand more to the price tag, and there is no guarantee that a material will pass the tests or that the test results won't raise further questions. Some manufacturers are turning to biological-safety literature reviews as a way of predicting the outcome of safety tests, and of sparing themselves the effort of rediscovering already established information. The article that follows is an example of such a technical report on the surface coating parylene C. Biological-safety literature reviews are not a new concept. Memorandum G states that "some devices are made of materials that have been well characterized chemically and physically in the published literature and have a long history of safe use.
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Literature Review: Biological Safety of Parylene C

Literature review biological safety of parylene c
Literature review biological safety of parylene c
Literature review biological safety of parylene c
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Literature Review: Biological Safety of Parylene C | anzaccentenaryschoollink.info

Richard F. What are the consequences of failing to comply with biocompatibility guidelines in the manufacturing of a medical device? For example, if an adhesive is used in the assembly of a device, but the adhesive does not come into contact with the patient, why must it still meet biocompatibility guidelines? Any medical device that comes into direct or indirect contact with a patient must be tested for biocompatibility. Even if a device doesn't physically touch the patient, in some cases it may release chemical constituents that could be harmful. The degree of concern about a material depends on its composition and the nature and duration of its contact with the patient.
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Biocompatibility Guidelines, Using EtO with Parylene

Neural probes are important tools in detecting and studying neuron activities. Although people have been working on neural probe development for a long time, the current neural probes including metal-wire probes and silicon neural probes are still far from being satisfactory. An ideal neural probe array should have good biocompatibility, high-density electrodes with high signal-to-noise ratio, flexible cables for interconnections, integrated electronics, and even integrated actuators to track neuron movement. The work of this thesis focused on applying parylene technology to neural probes development to make a new generation of neural probes with better functions.
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Whenever implantable devices come into contact with the human body, long term protection against body fluids, enzymes, proteins, and lipids is vital. Bio-medical surfaces typically require coating to protect from moisture, chemicals, and other potentially harmful substances. A downfall for wet chemistry, liquid coatings such as silicones, acrylics, epoxy, or urethanes is that they do not meet bio-compatibility requirements and cannot be applied with precise control. On the contrary, parylene does not out-gas and is very effective against the passage of contaminants from both the body to substrate or substrate to body.
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